1992. Miami. Lestat, Vampire-hero, rockstar, seducer of millions - is desperate to be free from the nightmare of his own immortality. Lestat yearns to be reborn a man, to think and feel and breathe like a mortal to walk in the sun, to regain his soul, and in a search for a return to mortality, travels through many lands and many times, from the New Orleans of today to 19th-century London, from 18th-century Amsterdam to the Amazon jungles. And all the while he is stalked by the one living being - the body thief - who covets Lestat's power and immortality and is only too eager too give him what he wants - his own mortal body.
Lestat, ignoring the warnings of those he trusts, ultimately surrenders his vampire body. The body thief vanishes. Chaos ensues and the newly mortal Lestat is left to discover what he has forgotten - the anguish of being human - the suffering, the weakness, the fragility of the ordeal of human life.